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Obesity is a metabolic disease characterized by high levels of fat. Previous studies have reported that Jambu Bol leaves (Syzygium malaccense (L) Merr. & Perry) have the efficacy of Antiobesity. To ensure safety, acute toxicity testing is carried out. The test animals used were 24 female white mice, divided into 6 treatment groups. Group 1 as a control group was given aquades. Group 2-6 was given ethanol extract of guava leaves with doses of 300, 1000, 2000, 4000 and 5000 mg / KgBB. The test is carried out for 14 days where the preparation is only given once. The parameters of the study included behavioral tests on the first and 14th day, body weight every day, macropatology of vital organs and organ indexes on the 14th day. The results of all doses of extract did not show a decrease in body weight, behavior changes and macropatological changes but there were differences in organ indexes, so that Jambu Bol ethanol extract can be declared not toxic.