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Interpersonal communication in nursing profession is a supporting factor for professional nursing services carried out to assist the healing process of patients. The purpose of this study is to determine the description of interpersonal communication between nurses and patients in inpatient installation at RSUD H. A. Sulthan Daeng Radja Bulukumba. This study was an observational research with a descriptive design and quantitative approach. The sampling method in this study was proportional random sampling technique obtained within 94 respondents. Furthermore, univariate analysis was used to analyzed the data by using SPSS to determine the frequency distribution of each dimension in research variable. The results showed that the interpersonal communication between nurses and patients in inpatient installation at RSUD H. A. Sulthan Daeng Radja Bulukumba on the openness dimension is 88.3% categorized in good category, empathy dimension is 51.1% categorized in good category, supportive attitude dimension is 67% categorized in poor category, positive attitude dimension is 84% categorized in good category, and equality dimension is 86.2% categorized in good category. Thus, it can be concluded that interpersonal communication between nurses and patients in inpatient installation at RSUD H. A. Sulthan Daeng Radja Bulukumba can be categorized as good. However, study suggest the hospital to improve interpersonal communication between nurses and patients and the hospital should conduct an effective communication training for all nurses.