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Metabolic syndrome and physical activity have a strong correlation to the gradual increased of degenerative diseases incidence in the global population. Currently, several approaches have been applied to prevent the progression of metabolic syndrome, including clinical drug therapy dan physical training program. However, limited data were found whether acute medium intensity exercise (AMIE) co-treated with middle rhythm musical exposure can affect to thermogenesis dan fatty acid oxidation. This study was designed by applying AMIE and music on 45 individual, non-professional athletes to evaluate the potential inducer of thermogenic activity (PGC-1α) profile in the muscle and adipose tissue. The preliminary finding of this study shows that AMIE exposure was significantly induced the increase of circulating PGC-1α as linear to the high-intensity exercise group, However, in contrary, the expression of this transcription factor tends to decreased post-AMIE-musical co-treatment. It is suggested that AMIE can induce thermogenesis in the skeletal muscle and adipose tissue by modulating oxidative phosphorylation within mitochondria. In summary, AMIE model may provide an alternative solution to combat metabolic syndrome linked obesity through enhancing the beta-oxidation process. Thus, the expanding investigation with a large sample and long-term monitoring program is required to establish this physical training program in the population.