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Background: Hepatitis B caused by hepatitis virus infection B (HBV) is a world health problem including Indonesia. Results of 2013 Basic Health Research estimated that there were 1,2% of the population in Indonesia with Hepatitis and East Nusa Tenggara was the province with the highest Hepatitis B prevalence (4,3%). Transmission can be through vertical (perinatal) and horizontal (house contact). Aims; The purpose of this study was to analyze the risk factors for transmission at home contact from students with HBsAg reactive. Methods; This study was performed in two phases. The first phases, November 2015, examination of HBsAg status with ELISA sandwich method was conducted on 341 students of Senior High School Kupang city obtained 45 samples with HBsAg reactive. The second phase, June 2016, out of 23 students HBsAg positive cases and 89 samples of family members were enrolled and evaluated. Of family members, 18 samples were found with HBsAg reactive, 6 subjects (33%) were fathers, 4 subjects (22%) were mothers, 5 subjects (28 %) were sisters and 2 subjects (11%) were brothers and 1 subject (6%) were others family members. Statistical analysis with Chi Square (X2) and Odds Ratio. Results: There is no significant relationship between HBsAg status with sex and age. There is significant relationship between HBsAg status with education, and marital status. The values were obtained (OR=0,184, 95%, Cl; 0,059-0,579) for education and (OR=0,204, 95%, Cl; 0,07-0,597) for marital status. Conclusion; The presence of family members with reactive HBsAg can transmit to other family members, 25% of family members also detected reactive HBsAg. More attention should be paid to HBV vaccination for family members of HBV patients.