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The Dengue Fever is an infectious disease which has always been one of the main health problems in Indonesian society. Dengue Fever is transmitted by Aedes Aegypti mosquito bites. The purposes of this study is to estimate the relative risk of spreading the dengue fever disease in Padang. Estimation is done using the Small Area Estimation method with the Empirical Bayes approach. Small area estimation is useful for estimating parameters in small subpopulations (areas) which have limited number of samples thus acceptable parameter values are hard to be obtained. In this study the construction of the model is based on Poisson-Gamma model and secondary data from Dinas Kesehatan Padang 2017 is used. This study resulted that for each district in Padang, the average relative risk of the spreading of dengue fever is almost the same, which are at medium and low level.