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The problem with bacteria resistance to antibiotics and antibacterial agents necessitates the development of powerful and effective antibacterial agents. Silver based materials such as silver nanoparticles or silver ions loaded in inorganic materials are examples of the effective inorganic antibacterial agents that can overcome this problem. They are known to have high antibacterial activity against wide spectrum of bacteria (Gram positive and Gram negative bacteria) even at low amount. However, the high usage of silver will create secondary problems which are environmental pollution and also possible bacterial resistance towards silver. Thus, one of the alternative approaches is by creating a hybrid organic-inorganic antibacterial agent using an aluminosilicate material such as zeolite or kaolinite as a carrier system for silver ions and functionalized the silver-zeolite or silver-kaolinite with suitable organic compound. This alternative approach enables lower amount of silver usage but maintaining the antibacterial efficacy due to the synergistic effect of organic compounds that attached together on the carrier system. Our group of research has successfully invented several hybrid antibacterial agents namely surfactant modified silver-zeolite, amine functionalized silver-zeolite, surfactant modified silver-kaolinite, chlorhexidine modified silver-kaolinite and aminoglycoside loaded surfactant modified silver kaolinite. The attachment of organic compound on the silver-zeolite and kaolinite changed physicochemical properties of the raw materials such as the charge was changed from negative to positive and becoming partially hydrophobic and hydrophilic but maintaining the structure of the carrier system. Furthermore, these hybrid antibacterial agents exhibited high antibacterial efficacy against Gram-positive and Gram-negative bacteria as compared to single antibacterial agent loaded on the carrier system. This research could pioneering more hybrid organic-inorganic antibacterial agents in the future since there are many other possible organic and inorganic materials can be combined together in the suitable carrier system and this could lead to lowering the vast usage of silver as antibacterial agent.