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The problem of reproductive organs which often experienced by teenagers is white discharge. White discharge or Leucorrhoea can be prevented by doing good vulva hygiene based on good knowledge. Increasing knowledge can be done by providing reproductive health education. The purpose of this study was to identify the effect of reproductive health education toward knowledge of white discharge prevention of students at SMP PGRI 5 Denpasar. This study employed pre-experimental design with one group pre-test post-test design. The population in this study was female students of first grade at SMP PGRI 5 Denpasar. There were 25 respondents recruited as the samples which were chosen by using the stratified random sampling technique. The data were collected by using pre-test and post-test questionnaires. It was analyzed by using Wilcoxon signed rank test. The result of the research showed that p-value = 0.001 and r = 0.62. It showed that reproductive health education significantly increased knowledge of white discharge prevention of the teenagers. The conclusion of this study is teenagers- knowledge increases after being given an intervention. Therefore, teenagers are expected to be more active in finding information how to prevent white discharge to avoid reproductive health problems.