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Development of the fetus in the uterus (embryology) was much mentioned in Al-quran and hadith. Along with advances in science and technology, especially in the digital era, reinterpretation of embryology with the multidisciplinary approach between Islam and medical sciences, especially embryology, is a challenge and a necessity so that Islamic teachings can be the right answer in overcoming the problems faced by the people. This study aims to analyze embryology in Al-quran and hadith in an expanded multidisciplinary perspective. This study used a library research method with a multidisciplinary approach between Islam and medical sciences, especially embryology. The result of the study showed that the stages of nuthfah, alaqah, mudhghah, and blowing of spirit already were formed within 40 days of pregnancy. These stages are embryologically more accurately translated as follows: nuthfah as the conception of a part of woman fluid (ovum cell) by a part of male fluid (spermatozoon cell), alaqah as resembling leech, something that attached to the surface, and something that depended, and mudhghah as resembling a chewed substance. Alaqah and mudhghah morphologically and functionally describe human characteristics that can be shaped and affected by environmental factors.