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Farmers and pesticide are two sides that are difficult to separate. Improvement of agricultural products is the hope of Farmers. Pesticides are chemicals used to eradicate pests that can increase farmers yields. The use of pesticides by farmers is increasingly growing, but not matched by the increase in understanding of the use of pesticides. The impact of the use of pesticides is the pollution of water, soil, air, and impacts on the health of farmers, family farmers and consumers. This research is quantitative research with cross-sectional design (cross-sectional), the samples were selected by simple random sampling conducted interviews and collection of samples of blood to 114 farmers in the agricultural area Alahan Panjang Farmers aged 19 to 49 years with an average of 28 years. High level of 63.2% knowledge, experience good skills 59.6%, and a good pesticide handling practices 71.9%. But are not included with the use of Personal Protective Equipment (PPE) which is 12.3% complete in the implementation of pesticide spraying. Adequate nutrition status 64.9% and a high activity of the enzyme cholinesterase 87.7% impact to lower health disorders consist of 22.8% 15.4% 84.6% cancer and gastrointestinal disorders. Analysis using logistic regression that nutritional status (OR = 3.7) and cholinesterase enzyme activity (OR = 6.6) is the main factor that impacts health problems to farmers. Higher education and a culture of using a complete PPE are important factors in overcoming the adverse effects of pesticides on farmers health