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There are many educational applications nowadays, which permit students to strengthen theoretical and/or numerical concepts as an interactive approach. This research presents an educational application to support acid-base titration “self-learning” in flipped science education. This educational application is based on an ad-hoc open MATLAB code, which aims to create acid-base titration curves as self-learning in an interactive and collaborative layout. With this flipped educational application, students can practice and repeat comprehensive titration alternatives, i.e. strong, weak or polyfunctional titration acids and bases. Also, for each titration, each compound in different concentration can be chosen as the titration for the science education. The results show the proposed educational application as “self-learning” plans the titration curve, the former curve derivative and the numerical results. Particularly, students can have the opportunity to compute and analyze the titration-s final point graphically and numerically. Therefore, this flipped educational application is a possible and practical method to develop the fundamental concepts of acid-base titration via the numerical exercise practice supported by computer-based design.