Analysis of Wicking and Passive Mixing Characteristics in Fabric-based Flexible Microfluidics Akhmad Dyma H. S. (a*), Jessika (a), M. Yusreza Irsyan (a), Isa Anshori (a), Brian Yuliarto (b), Dedy H. B. Wicaksono (c)
a) Department of Biomedical Engineering, School of Electrical Engineering and Informatics, Bandung Institute of Technology, Jalan Ganesha 10, Bandung 40132, Indonesia *akhmadyma[at]students.itb.ac.id b) Department of Engineering Physics, Faculty of Industrial Technology, Bandung Institute of Technology Jalan Ganesha 10, Bandung 40132, Indonesia c) Department of Biomedical Engineering, Faculty of Life Sciences and Technology, Swiss German University, The Prominence Tower, Jalan Jalur Sutera Barat 15, Tangerang Selatan 15143, Indonesia
In the past few years, various studies on the diagnostic medical field have been conducted which have resulted in the development of wearable devices for biomedical applications. It was concluded that POCT platform should be low-cost, easy to use, and portable. Fabric is an interesting platform for point of care testing because it has inexpensive material and enough scalability and specification. In this project, wicking and passive mixing properties in fabric-based flexible microfluidic system were investigated. The fabrication was done with a low-cost method using batik wax patterning method to divide the hydrophilic and hydrophobic area. A mixture of samples with food coloring was dropped on the hydrophilic area using pipetting method. Wicking and passive mixing then analyzed by observing the critical zones around the junction channel. The hydrophilic channels wick the analyte across the chamber region by natural capillary action, allowing the color to change in shades upon reaction. The initial proof of concept was done by using food coloring experiment and the analysis was indicated by color changes of the area. Analyses were carried out using PC-connected digital microscope and computer-aided image software analysis ImageJ to observe geometric dimensions and measure changes in color intensity level so that the wicking and mixing properties such as sample capacity, flow rate, and the other mixing effectiveness parameters can be found. The results of this study can be utilized for future improvement of low-cost and flexible microfluidic device for POCT application in developing countries.