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Propolis is component of honeycomn and has many benefist fot treatmemt the concent of the chemical and its compositiaon are complex, making propolis had various properties, including anticancer or antitumor, antifungial antibiotic and immunomodulator. Tje kidneys is the mains organs that often experience interference due to the toxic effect of commpound, cause the kidneys have a higj blood volume flow and concentrate toxic substance the glomerular filtrate and carry through tubular cell. Purpose of this reserch is to determine the effect of administration propolis extract on necrosis of proxinal tubular epithelial cell of male mice. This research is an expwrimental study of randomize block design with 6 treatmentd . 24 male mice aged 8 weeks was given propolis extract through gastric sonde at dose of 10mg/kg 20mg/kg 30mg/kg 40mg/ kg 50mg/kg and PO given water. After 18days micr in the dislocation and kidney organs mad3 histology preparation with hematoxylin eosin. Each preparation were observed in 2 slide of 4 transversed slice of tje kodney. Each slice observed 3 flieds of view and each field of view is observed in 10 tubule and calculates the nucleus cell thta piknotic karyorexis karyolisis. Analyze the data using a one way anova on the 95% level followed by duncan. the ewsult show propolis extract had a effect to proximal tubular necrosis. The content of tannin and alkaloids propolis is though to have the potential to cause cell membrane damage so that ion transport is disrupted. Resukting in uncontrolled inclusing of ca ions and causing cell death. Doses 10mg/kg began to influence the proximal tubular necrosis mice