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Preparation of Chitosan-Honey-Gelatin-Based Hydrogel for Active Material of Wound Care Dressing Application
Widya Ernayati Kosimaningrum, Dhena Ria Barleany, Vera Nita Sako, Riska Ristiyanti

Department of Chemical Engineering, Faculty of Engineering, Universitas Sultan Ageng Tirtayasa, Jl. Jendral Sudirman km.3 Cilegon, Banten


Abstract

A dressing is usually applied on the wound care product to help healing process and prevent an infection as well as a complication. Many serious wounds such as heavy burns, diabetic wound, and surgical wound are requiring special dressing which has both antibacterial and proper wound drainage management properties to promote faster healing. Hydrogel composed of chitosan, honey, and gelatin can be a good candidate which provides match properties as required. Preparation of hydrogel has been conducted by physical mixing of the solution of chitosan, honey, and gelatin at 40oC. Then, the mixture was casted to form hydrogel films by each 2-4 mm thickness and followed by drying at 37o C for 24 hours. The resulted hydrogels are characterized to confirm its potential as wound care dressing by measuring gel fraction, swelling index, and antibacterial activity. The gel fraction of the hydrogel composed of 10 and 20 grams of gelatin (each with 0.5 and 20 grams of honey) was achieved respectively 68,86 % and 65,68%. The gelatin composition more than 20 grams led to lowering gel fraction significantly. The swelling index of hydrogel with 20 grams gelatin show almost four times higher. Reducing honey composition to 10 grams of hydrogel has improved both the gel fraction (about 25 %) and swelling index (about 12 %). These two properties have been improved further by increasing the chitosan composition up to 7.5 grams. However, the effectiveness of honey composition as antibacterial in hydrogel is still need to be further evaluated.

Keywords: hydrogel, chitosan, honey, gelatin, wound dressing

Topic: Chemical Engineering

Link: https://ifory.id/abstract/Vr2u7xRzhMZb

Conference: Broad Exposure on Science and Technology (BEST 2019)

Plain Format | Corresponding Author (Widya Ernayati Kosimaningrum)

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