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Escherichia coli is a Gram-negative bacterium that has a natural habitat in the human digestive tract. This bacterium besides being a normal flora can also be pathogenic. Escherichia coli is the most common cause of diarrhea. Guava leaves and bay leaves contain essential oils, tannins, flavonoids, and saponins which have antimicrobial effects. The purpose of this study was to determine the difference in the effectiveness of inhibition between ethanol extract of guava leaves and bay leaves on the growth of Escherichia coli bacteria. This type of research is an experimental laboratory. The inhibitory test was carried out by measuring the clear zone around the paper disc using callipers. The results of data analysis using one way ANOVA showed that there were significant differences between groups of extracts with F output = 49.83 and p = 0.00 (p&