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Poliherbal Bioactive Compounds Demonstrate Therapeutic Potential against Lung Cancer Incidence
Wira Eka Putra1, Viol Dhea Kharisma23, Hendra Susanto1*

1Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang
2Division of Genetics and Molecular Biology, Generasi Biologi Indonesia Foundation
3Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University

*Corresponding Email: hendrabio[at]um.ac.id


Abstract

The effect of the smoking alter the broad biological system and causing the negative effect including cardiovascular diseases, immune and metabolic disorders, and cancer. On the other hand, numerous strategies to suppress the dependency to the cigarette has come to its limit. Therefore, the new approach to face the undesired outcome is necessary. This study aims to evaluate the pharmaceutics potencies of bioactive compounds from several Indonesian medicinal plants. The 2D structure of poliherbal compounds were collected and prepared for the docking processes. On the other hand, the 3D structure of human α-3 NAchRs protein was retrieved from PDB. Virtual screening approach was occupied to observe the molecular interaction among ligands and the targeted protein. The value of binding energy was used to determine the potency of poliherbal compounds as inhibitor candidates against α-3 NAchRs protein. The result of this study showed several compounds that might possible as inhibitor against α-3 NAchRs. Here, we classified the top three compounds that have minimum energy binding, namely Asiaticoside (-12.2 kcal/mol), Orthosiphol B (-9.8 kcal/mol), and Panduratin A (9.0 kcal/mol). Our finding suggests that the poliherbal might potential as complementary supplement for smoker to avoid the adverse effect of cigarettes.

Keywords: Cigarette, human α-3 AchRs, poliherbal compounds

Topic: Bioinformatics

Link: https://ifory.id/abstract/WL7U6JRDkpYr

Conference: International Conference on Life Sciences and Technology (ICoLiST 2019)

Plain Format | Corresponding Author (Wira Eka Putra)

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