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Whiteleg Shrimp Shell Powder (WSSP) contains astaxanthin (AST) that can ameliorate diabetic condition. This research was aimed to examine and compare the effect of WSSP and AST supplement on homeostatic model assessment-insulin resistance (HOMA-IR) and total antioxidant capacity (TAC) level in type 2 diabetes mellitus rats induced by high fat diet- Streptozotocin (HFD-STZ). Thirty rats used in this study were group in five. Control groups without any treatment were diabetic rat (K1) and healthy rat (K2) group. Treated groups of diabetic rat were X1, X2, and X3. The treatments were administered orally for 21 days. X1 and X2 groups were received WSSP doses of 0.89 gr/kg/d and 1.77 gr/kg/d respectively, while X3 group was treated with AST in dose of 0.09 mg/kg/d. HOMA-IR and TAC levels were measured by ELISA and ABTs method respectively. Data were analyzed using Paired T-test/Wilcoxon and ANOVA/Kruskal Wallis test. HOMA IR levels were significantly lower in treatment groups than (K1) group (p<0.05). The decrease HOMA IR levels of X2 group was more than X1 group (p<0.05). TAC levels were significantly increased in treatment groups than (K1) group (p<0.05). The increase TAC level of X2 group was greater than X1 group (p<0.05). Based on the result above it can be concluded that WSSP at dose of 0.89 gr/kg/d and 1.77 gr/kg/d can ameliorate type 2 diabetes mellitus.