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The aim of this research is to (1) make a Mobile Media Learning on Acid and Base and to determine the quality of the media produced, (2) determine the feasibility of the media used in learning process. The subjects of this research were students of SMAN 54 Jakarta, SMAN 42 Jakarta, and 7 chemistry teachers. The research was conducted from January to May 2018. The method used in this research is Research and Development (R&D). The steps performed in this research are: (1) needs analysis, (2) developing mobile learning, (3) validation test of mobile learning media, (4) media testing by students and small scale of teachers, (5) media trials by students and teachers on a large scale. The results obtained from expert validation tests, small class trials, large class trials, and effectiveness of the media, it can be concluded that the mobile media learning developed in this research is good enough to use in the learning process. The n-gain value obtained from the effectiveness test is 0.76 which can be categorized as high effectiveness, based on the Paired t-test the Tcount value is 28.048. The paired t-test value is Tcount>Ttable (2.03), the value of significance obtained from the paired t-test is 0.000 which is less than the level of significance (α) = 0,05, therefore H0 is rejected so it can be concluded that there is a significant difference between pre-test score and post-test score. That difference means that there is improvement in students average score after using the mobile media learning.