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Compounds in plants can inhibit or even kill cancer cells so that they have the potential as anticancer agents. One of the potential plants as an anticancer agent is the annonaceae family. This reserch as a screening method using Brine Shrimp Lethality Test is to find out the cytotoxic activity of soursop leaves, srikaya leaves, and nona leaves. The result of the preliminary test of cytotoxic activity of ethanol extract of soursop (Annona muricata L), srikaya (Annona squamosa L) and nona (Annona reticulata L)leaves showed cytotoxic activity wilth LC50, respectively 30,90; 38,01; dan 46,77 ppm. Based on the results of the study all extracts have cytotoxic activity. The highest cytotoxic value was shown by soursop leaf ethanol extract with LC50 value of 30,90 ppm.