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Every injury causes a systemic inflammatory response syndrome (SIRS) in a short time, including head injury. SIRS reflects the existence of systemic inflammation that is considered and allows the increasing problems and poor outcomes if the criteria are realized for a long time. The aim of study was to determine an association between SIRS and mortality of head injury patients that calculate using the GAP score. This study was an observational analytic with 85 head injury patients were observed for the SIRS and GAP scores when they got emergency treatment at the emergency department, Ulin General Hospital Banjarmasin. The data were analyzed using the Spearman trial. The data showed a strong negative relationship between SIRS and GAP scores in head injury patients. It meant that patients with positive SIRS have a high likelihood of death. Therefore, it was important to measure the SIRS among head injury patients.