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Cancer-related fatigue (CRF) has been the most important symptom and sadness in cancer patients that can affect the patient-s quality of life. However, there is no study related to CRF conducted in Bali. The aimed of this study was to describe CRF in outpatient of cancer patients at Mangusada Badung Hospital. This study employed descriptive design with cross-sectional approach. The population of this study was 296 respondents who registered as outpatient of cancer patient; however, there were only 160 respondents recruited as the sample through non-probability sampling with consecutive sampling technique. The data were collected by using Brief Fatigue Inventory (BFI) questionnaire and analyzed by using univariate analysis. The findings indicated that 36.9% of respondents aged 51-55 years, and the majority of respondents had rectal cancer about 35.6%. According to fatigue category, there were 2.5% respondents had mild fatigue, 20% with severe fatigue, and 77.5% of respondents had moderate fatigue. The important changing of this study is that enjoyment of life change 7.5% among 6 whole changing. It can be concluded that patients with cancer have decreased in the quality of life. It is expected that the service provider can provide appropriate interventions to reduce the fatigue level in cancer patients.