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The combination between herbs and antibiotics might be promising strategy for antibiotic resistance. Abundance studies have been denoted that certain herbs have important roles in bacterial destruction proccess. As an antibacterial, previous study reported that Syzygium polyanthum (bay) leaf extract caused disintegration of bacterial surface and lysis of the bacterial intracellular component. The aim of this study was to determine antibacterial synergistic activity of S. polyanthum leaf extract and chloramphenicol. Staphylococcus aureus was significantly inhibited after treating with high dose of chloramphenicol and low dose of S. polyanthum decoction in disk diffusion test (26 ± 1.52 mm of inhibition zone) in the comparison with low dose of S. polyanthum decoction treatment only (5 ± 4,61 mm of inhibition zone, p <0,05). Similar results were found by combining low dose of chloramphenicol and low dose of methanol extract of S. polyanthum in disk diffusion test (17 ± 0.57 mm of inhibition zone) in the comparison with low dose of methanol extract of S. polyanthum treatment only (7 ± 5,85 mm of inhibition zone). In conclusion, this study suggests that Syzygium polyanthum leaf extract synergizes with antibiotic and has potential as a therapeutic agent for antimicrobial chemotherapy.