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Counseling is a process of systematic two-way communication between the pharmacist and the patient to identify and solve problems. Counseling is very important, especially for patients with specific diseases that are chronic such as cardiovascular disease (CVD). The main risk factors in CVD is uncontrolled hyperlipidemia. Hyperlipidemic patients must undergo treatment in a long time and requires high compliance to take the medicine well and good lifestyle changes in order to achieve better therapeutic results. To achieve all that is needed appropriate counseling methods and according to standards. Therefore, this study aimed to determine the effect modification counseling methods to the results of treatment of patients with hyperlipidemia. This research method is done by using a quasi-experimental approach is to intervene through counseling in the treatment of hyperlipidemia patients were grouped into two groups: a control group that will be given verbal counseling alone and test group who will be given counseling modification by using the tools of leaflets and video, as well as the monitoring will be conducted by telephone. The number of samples is required in this study were 72 patients ie 36 patients as the control group and 36 patients as an experimental group. The result shows that perception and behavior of experimental group experienced a greater change compared with the control group. Perception and behavior prior to counseling included in good category, and after counseling, the patients perception and behavior turn into the excellent category based on the Likert scale. Results of treatment of patients with hyperlipidemia which is lipid profile shows the p value 0.000 <0.05, which means that modification counseling methods have a significant influence on the change of therapy results hyperlipidemic patients who use statins.