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Cyber-physical system (CPS) as one of the aspects in the cyber-system of industrial revolution 4.0 is currently widely used by industry for its development. The integration of computation and physical process control in line with technological development benefits from its implementation. Vocational Education as a provider of labor in the industry must respond to CPS through teaching factories so that it is inline in the Industry. The purpose of this paper is to analyze the concept of CPS that is applied in the current industry. The method used in making this paper is a systematic literature review. The paper search results illustrate that CPS is a management model in the industry that applies the principle of technology integration. The working principle of the CPS-based industry has the characteristics of the integration of cyber human systems and cyber-physical systems. CPS has been widely used in the current industry, but has not yet been developed in vocational education so that it will widen the gap between the industry and vocational education. Need further research for the development of CPS in vocational education