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Oral cancer requires extensive excision and neck nodes management. Neck dissection can be excessive and cause postoperative morbidity. This study aims to determine whether the clinical examination and CT Scan can be a predictor of metastatic lymph nodes (pathological) of oral cancer. This study is a diagnostic test, analytic observational with cross sectional design. The population are patients with oral cancer T3-T4 / N0-N1M0 treated at Dr. Soetomo Hospital, period of January 2015 - February 2017. There were 19 patients, male-female ratio is 2.6:1. The average age is 50.7 years (ranged 24-76). Clinical examination has an accuracy of 62.5% as a predictor of lymph nodes metastatic of oral cancer (p = 0.883). CT Scan has an accuracy of 73.9% (p = 0.018). This study concluded that CT Scan is more powerful predictor of regional metastatic oral cancer than clinical examination.