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ABSTRACT: This study was to determine the effect of self efficacy, job involvement, burnout on stress of work nurses of International Hospitals at Jakarta. The object of this research is nurses who work at International Hospitals. This study was conducted on 129 respondents using a quantitative descriptive approach. The results of this study show that the workload variable has a significant negative effect on stress of work, job involvement has a significant positive effect on stress of work and burnout has a significant positive effect on stress of work. The approach used in this study is the Structural Equation Model (SEM) with a Smart-PLS analysis tool. Therefore the results of this research test state that there is a joint effect between self efficacy, job involvement and burnout variables on stress of work at International Hospitals.