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Abstract Objective: The insidence rate of microbial exposure remains high among nurses. Paramedics play a vital role in transmitting the nosocomial infection in the hospital. This research aims to analyze the education effectivity of MRSA IPC with directive discourse to improve handwashing compliance among nurses. Methods: This is a quasi-experimental research using pretest-posttest non-control design and has obtained an ethical approval certificate issued by the hospital ethical committee. The research subject is a group of 25 nurses. Results: The data test uses Wilxocon test to determine the measuring result of handwashing compliance before and after the treatment. The value of p = 0.018 (p < 0.05) means there is a difference before and after the treatment. As the handwashing awareness increases, so does the compliance. Conclusions: The education of MRSA IPC with directive discourse is effective to improve the handwashing compliance among nurses in the hospitals.