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Background Fractures are among the most frequent type of injuries in patients exposed to traumatic injury. There is increasing evidence that exposure to electromagnetic radiation can affect human health. Electromagnetic radiation stimulation is known to affect biological activity on related to fracture healing. Low-frequency electromagnetic radiation exposure has been utilized widely for supporting therapy to enhance fracture healing. This study aimed to evaluate the effects of exposure to electromagnetic radiation at a frequency of 2600 MHz (the frequency of fourth-generation cellular phones) on the healing of femur fractures in rats treated with ORIF K-wire. Methods. The study was carried out with 22 mature male Wistar rats. Femur osteotomy and fixation with open intramedullary wire were performed on all rats. The rats were preoperatively divided into two groups using simple random sampling, –a control group and an experimental group. Only the experimental group was exposed to electromagnetic radiation at a frequency of 2600 MHz for 30 minutes daily, five days per week for 2 weeks. Histopathological tests were conducted 2 weeks after the operation. Result. The Mann Whitney test score showed fracture healing was statistically significantly higher in the experimental group than in the control group (p<0.05, 3.55±0.69- and 5.91±0.83, respectively). Discussions. The thermal and non-thermal effects of electromagnetic radiation exposure have been shown to promote the proliferation phase of fracture healing due to radiation hormesis. Conclusions. High-frequency electromagnetic radiation exposure at 2600 MHz enhances the proliferation phase of the femur fracture healing process.