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Background: Palliative care is the treatment needed by patients with life-limiting ilness (LLI). LLI patients can not be cured but can be treated with lifestyle management and spiritual management. Some spiritual disorder was found in LLI patients such as negative feeling, frustrated, angry and feel different from others, lonely entertainment, anxiety and low self esteem. Spirituality had been proved can increase of self esteem, emotional wellbeing, and give some hopes. LLI condition only affects the patient, but also the family as a caregiver. The impacts that might be experienced by the families include economic problem, stress, and depression which can lead into health problems and death. Aims: This study was conducted to determine the spirituality of the LLI patients and stress in their family care giver. Method: This crossectional study involved 40 patients and 40 family care giver. The results of this study indicate that the level of spirituality of patients LLI was more than the middle value with a score range 0-48. While the average value of three spiritual components is belief (13.5), meaning (10,7), peace (9,9). The study also showed that most of the caregivers experienced stress which caracteristized; feeling burdened (52.5%), crying without control (45%), feeling stressed (30%), and experiencing poor health condition (22.5%).