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Background: Simulation based training has been adopted in the clinical area to improve nurses knowledge and skill to recognize and respond to the deteriorating patients. However, the use of simulation training needs high-technology, professional trainer, funds, and simulation laboratory. Recently, innovation in conducting simulation-based training is increasing and is intended for clinical nurses. Method: This literature review searched relevant online database including CINAHL, Scopus, Science Direct, and PubMed to gather relevant studies. Results: Twelve articles demonstrated that simulation training could increase the clinical nurses competence to recognize and respond timely to the deteriorating patients, and it has a potential effect to increase patient outcome. Only one research demonstrated that simulation training is worth to conduct and could reduce the additional cost in the hospital. Conclusion: Simulation training provides value as an effective method to educate general unit nurses in managing the deteriorating patients and potentially has benefit for patient outcomes and saving the additional cost.