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Diabetes mellitus is a clinical syndrome of metabolic disorders, characterized by hyperglycemia caused by defects in insulin secretion, insulin working defects or both. In the world, the number of people with DM is estimated at 171 million and this condition is predicted to continue to rise to 366 million by 2025. The aim of this study is to prove that prodiabetica bitter syrup can reduce blood sugar levels in experimental animals Method: experimental research in laboratory using randomized group design with 5 variations of experimental animals groups. Measurement of blood sugar levels (mg / dL) was carried out 4 times, namely the measurement of initial Blood Glucose Levels after rats were given Streptozotosin (STZ) people with diabetes (P1).Measurement of blood glucose levels were carried out in the second week (P2), and measurement Blood Glucose Levels were carried out in the third week ( P3). The researcher gave Prodiabetic bitter melon syrupwith raw materials, which were bitter melon which had been boiled and then mashed, and then made syrup. The research samples were 25 wistar strain white rats which were divided into 5 groups with 5 groups each. Analysis using General Linear Model with significance level (α = 0.05) or CI = 95%. The results : there were differences in the mean difference between the administration of glibenclamide 0.09 mg/200 gram weigth (40.77 mg/dL), administration of bitter melon syrup 0.27 ml/200 gram weigth (34.19 mg/dL) and combination of administration glibenklamid 0.09 mg / 200 gram weigth and administration of bitter melon fruit 0.27 ml / 200 gram weigth (51.17 m /dL). There were significant differences between the 5 treatment groups with a pvalue = 0,000. Conclusion: there is a significant difference between the combination of Prodiabetic bitter melon syrup and glibenclamide to decrease blood sugar levels in experimental animals.