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Modisco (Modified Dietetic Skimmed Milk and Coconut Oil) is a nutritious and high-calorie formula in the form of liquid food that was made from skim milk or full cream, sugar, and oil or margarine. The addition of soybean flour was given to increase the protein content which is intended for alternative handling cases of protein energy deficiency. This study was developed to analyze the effect of the modification of Modisco III formula by adding soybean flour to the growth of malnutrition rats. The design of this study was a pre-post test control group using 24 Wistar male rats which were treated malnutrition, which was divided into 4 groups. Control (-): low protein feed, Control (+): standard AIN-93G feed, Treatment (1): Modisco III soybean feed, and Treatment (2): Modisco III soybean meal + cassava flour. Based on the analysis of varians (ANOVA) there was a significant difference on the weight and body length between group (p <0.0001). The addition of soybean flour on the modified Modisco III had influenced on the weight and body length (p <0.0001) as well as on the growth of malnutrition rats.