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This research begins several studies of management practices and how antecedents affect the performance of public hospital. The research hypotheses were tested using the survey data from 13 public hospitals in South Kalimantan, Indonesia. Pearson zero-order correlation was used to analyze hypothetical relationships. By using SPSS 23, the regression test is done by first the Classical Assumption test. The results of this study found that certain antecedents such as performance measuring and institutional culture have significant positive association with public hospital. Thus, this study provides an opportunity for public hospital to redesign, redefine, and formulate policies for improving their previously unheartening performance. This research is also a recommended that more performance management mechanisms are needed to complement and improve the public sector efficiency.