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This study aims to analyze the effect of entrepreneurship education, family environment and self-efficacy on the interests of student entrepreneurship. The population in this study were 365 students of Management at the University of Mercu Buana Jakarta. The sample used was 191 respondents, calculated based on Slovin formula. The sampling method uses convenience sampling. The method of collecting data uses a survey method, with the research instrument being a questionnaire. Data analysis method uses Partial Least Square. This study proves that entrepreneurship education does not influence the interest of student entrepreneurship. The family environment does not influence the interest in student entrepreneurship. Self-efficacy has a positive effect on the interest of student entrepreneurship.