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Background: The high number of patients falling for a year in a hospital is a serious problem in the hospital because the incidence of falling patients is one indicator of patient safety. The purpose of this study was to analyze the effect of the application of fall risk prevention management and training on the implementation of patient safety with the leadership role of the head of the room as an intervening variable. The research uses quantitative research methods with questionnaires survey and Structural Equation Model (SEM) analysis methods, Amos version 23. Research samples are 178 nurses who have received patient safety training. The test result on the model has met the Goodness of fit criteria. The results of this study indicates that the risk reduction prevention management variable has a positive effect on patient safety. Training has a positive effect on patient safety management. The implementation of falling risk management has a positive effect on the leadership role of the head of room, training has a positive effect on patient safety management, training has a positive effect on risk management the leadership role of the head of the room has a positive effect on patient safety. The direct coefficient of patient risk falls on patient safety is greater than the indirect coefficient which shows there is an indirect effect of the patients risk of falling on the implementation of patient safety through the leadership role of the head of the room. The coefficient of directors training on patient safety is greater than the indirect coefficient which indicates there is an indirect effect of patient safety training on the implementation of patient safety through the leadership role of the head of the room.