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Green Chemistry principal was introduced in an academic environment in the 1980s as guidelines for sustainable development focused on chemistry. Efforts to realize these expectations can be applied through education by developing learning process based on environmental. This study aims to apply the concept of Green Chemistry in education, especially chemistry learning by producing natural acid-base indicators from the extract of roses (Rosa sp) and Rosella (Hibiscus sabdariffa L). These indicators are produced by the method of extraction using 96% ethanol solvent in an acidic atmosphere at pH 3-4. The results of maceration then extracted in three different solvents (ethanol, n-hexane, and chloroform). The extract was tested in solution with pH 1-12 and used as an indicator to identify the solutions and titration in acid-base topic. It concluded that the roses and Rosella can be used as an alternative raw material for acid base indicator. The use of roses and Rosella indicates an attempt to have applied the principles of green chemistry, including the prevention of the formation of hazardous wastes, the design of safe chemical products, the use of renewable materials, the design of materials that are easily degraded, and the use of safe solvents.