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Pulutan (Urena lobata L.) is a type of plant that is widely used as traditional medicine. The compound in pulutan leaves consists of alkaloids, tannins, triterpenoids, flavonoids, saponins and steroids that work as antifertility agents. The purpose of this study was to determine the effect of giving pulutan leaves (Urena lobata L.) simplicia to the number of follicles of mice (Mus muscullus) Balb-C strain. This study used a Randomized Block Design (RBD) with six treatments giving pulutan leaf simplicia decoction (Urena lobata L.), namely 0%, 5%, 7.5%, 10%, 12.5% ​​and 15%, respectively the treatment repeated four times. Giving treatment for 15 days begins during the metestrus phase. The data tested for normality, homogeneity test, and analyzed by single ANOVA, and if they affected, it continue with Duncan test with P <0.05. The results of this research showed significant differences between the control group and treatments in the analysis of monolaminar primary follicles, multilaminar primary follicles, secondary follicles, de Graaf follicles and atresia follicles. Concentration of decoction simplicia pulutan leaves 7,5% begin to reduce the number of multilaminar primary follicles, and de Graaf follicles and begin to increase the number of follicles atresia, whereas at the concentration 10% begin to reduce the number of monolaminar primary follicles and secondary follicles. The conclusion of this study is that pulutan leaf simplicia decoction (Urena lobata L.) can reduce the number of follicles in monolaminar primary follicles, multilaminar primary follicles, secondary follicles, de Graaf follicles and increase the number of atresia follicles.