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Background: Hospitals are very complex and high-risk institutions, especially in regional and global environmental conditions that are very rapidly changing. For that medical service staff must always try to innovate and improve the performance and service system in order to achieve excellent service, one of which is in carrying out emergency actions that occur. Emergency cases that often occur are cardiac arrest cases where each hospital should have an standard operational procedur in basic life support measures. This study wanted to know the level of knowledge and skills of nurses about basic life support in management patient of cardiac arrest in Panembahan Senopati Bantul Hospital. Research Method: The type of research conducted is the mix method. For the quantitative approach using descriptive observational methods while for the qualitative approach is obtained by doing deep interviews. Result: From 42 respondents who were given a basic life support knowledge questionnaire, they got mean 16,142 while checklist standard operational procedur of basic life support got mean 9,952, which meant nurses at Panembahan Senopati Bantul Hospital had good knowledge and skills about basic life support. Implementation that occurs is still not in accordance with established standards. Conclusion: The results of this study are nurses in Panembahan Senopati Bantul Hospital who have good knowledge and skills about basic life support in the management of patients with cardiac arrest. But in its application in the field it still hasnt gone well because there are gaps in the application of existing standard operation procedure.