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This research was aimed at gaining a worksheet learning media with the steps of Problem Based Learning approaches for the learning of Medical Electronic Practice. This research adapted the development model of Alessi and Trollip consisting three steps, namely planning, design, and development. Product test design used was alpha testing. The data collection technique used was interview, documentation, observation, and questionnaires. The data analysis technique used was qualitative descriptive analysis. The results of this research showed that, in general, the worksheet of Medical Electronic Practice developed in this research got the average score 2,97 which was in the suitable category. This worksheet assessment was identified from five assessment indicators, namely graphics, material presentation, Problem Based Learning characteristics, suitability, and usage. Thus, the worksheet of suitable category was able to be applied in the learning of Medical Electronic Practice.