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Recent trend in health care demonstrates the significant use of herbal as preventive or therapeutic strategy against multiple type of diseases including respiratory disorder. Thus, in this present study we aims to explore the potential of black tea phytochemical compounds as inhibitor against human α-3 nicotinic acetylcholine receptors. The 2D structure of black tea compounds were retrived online from PubChem data base. On the other hand, the 3D protein structure of human α-3 nicotinic acetylcholine receptors (NAchR) was obtained from protein data base. Protein-ligand preparation were proceed to optimize the molecular interaction results. The final step of this screening is performed data visualization and analysis. In this study, we found that there are three potential compounds that might be act as inhibitor for α-3-NAchR considering of its energy free binding. Thus, this results indicate that the black tea bioactive compounds might be potential to develop as inhibitory agents for α-3-NAchR to minimize the negative effect of nicotine.