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Sleep is one of the primary needs of the basic requirement for human survival. Sleep disorders can cause some effect in humans. It is estimated that 60-80% of workers with shift work system have impaired sleep quality. This results in a decrease in work productivity and an increase in the occurence of accidents. This study aims to determine the determinants of sleep quality disorders nurses in Tabanan General Hospital. This study used cross sectional analytical observational method by conducting questionnaire based interview. The study population was nurses in Tabanan General Hospital with sampling using consecutive sampling technique with samples of 94 people. The results of this study found that factors that have a statistically significant relationship with the quality of sleep is married / have a marital status (PR = 5,53, IK 95%: 1,50-20,39, p <0,05), nurses with tollders (PR = 3,88, IK 95%: 1,28-11,71, p < 0,05) and work system shift (PR = 19,46, IK 95%: 2,48-152,69, p < 0,05). While the factors that have not statistically significant relationship were sleeping environment (PR = 2,06, IK 95%: 0,72-5,91, p=0,17) and coffee consumption in high quantities (PR = 1,41, IK 95% : 0,53-3,73, p=0,48). Based on the result of research, it is found that marital status, toddler ownership and work system are the determinants of nursing sleep quality disorder in Tabanan General Hospital.