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Community empowerment, especially for women, needs to be done so that economic prosperity increases both for cadres and the surrounding environment. Increasing entrepreneurial interest for cadre ladies can be seen by using the variables of self efficacy, social media, family environment and the spirit of entrepreneurship. The aim is to be able to implement the posyandu cadre strengthening model in building social entrepreneurs. This research was conducted on 36 respondents who came from the cadres of Tanjung Morawa Sub-District, Deli Serdang District. The study was conducted by distributing questionnaires to respondents and conducting FGDs. The analytical method used is descriptive analysis method and multiple regression analysis method using analytical tools is SPSS. The results obtained in this study are that self efficacy has an influence on entrepreneurial interest in cadre ladies. Whereas the family environment has a positive but not significant effect on entrepreneurial interest in cadre ladies. Furthermore on social media shows that there is no influence and no significant effect on entrepreneurial interest for cadre ladies, and the last result for the spirit of entrepreneur has no influence and is not significant on the interest of cadre ladies in entrepreneurship. And for simultaneous test on Spirit Of Entrepreneur, Social Media, Family Environment, and Self-Efficacy, significant influence on Entrepreneurial Interest in cadre ladies Tanjung Morawa Sub-district.