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This research is motivated by concerns about the low achievement of students spiritual competencies, even in Islamic schools. One of the reasons is the limited availability of teaching materials that can help teachers to associate science subject towards Islamic values. Even though, teaching materials are an important part to determine the success of the learning process. In Islamic schools, teachers are required to internalize Islamic values into the subject, including in chemistry. Unfortunately, not all teachers understand the process of internalization in any chemical material taught. One of them is the buffer solution material. The aim of this research is to examine the process of internalization of Islam into buffer solutions teaching materials. The analytical method in this paper is based on scientific integration between general science and religious science (non-dichotomic). Internalization of Islam in buffer solution teaching materials conducted by including the verses of Quran and hadith that are related and strengthening the material in the form of case studies of the phenomenon of buffer solutions in everyday life and doing exercise. Based on the research, teachers and students gave a positive response to the procurement of teaching materials which internalized in Islamic values.