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Abstract. Education plays important role to form attitude related to the health. When immune system does not work properly it allows microorganism to attack. In the reality most of high school students do lack of knowledge about infectious diseases. With regard to this issue, the current study was carried out to examine student knowledge about infectious diseases related to immune system. The samples of this study was eleventh grade students of SMAN 5 Banda Aceh. The method that used in this study is observation method. Data of student knowledge about infectious diseases was obtained from essay test, whereas the data of student motivation and ability to receive information were obtained from the test that provides yes or no question. The data were analysed by percentages correction and analysis. According to the data the result are all students have low knowledge about infectious diseases whereas the students have good motivation to learn biology and good ability to receive biology information. Based on this study the conclusion is the students in eleventh grade have low knowledge about infectious diseases that has no relation with student motivation and the ability to receive information.