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End-stage renal disease (ESRD) is one of the public health problems in Indonesia. This study aims to determine the condition of premorbid clinics with the incidence of ESRD. The study design in this study is a case-control with a comparison of cases: the control is equal to 1: 1. Based on the calculation of the sample size of at least 44 patients, the number of volunteers involved in this study was 100 people. The cases were ESRD patients who were determined by the criteria of Pernefri and as controls were patients from the same hospital who were not by the requirements of ESRD Pernefri adjusted for cases based on age and sex. Inclusion criteria of the study sample (1). ESRD sufferers need routine hemodialysis and doctors diagnosis supported by laboratory data; (2). Indonesian citizen; (3). 15-75 years old; (4). Willing to fill out consent information, and (5). Exclusion criteria for the study sample (1). Patients with congenital kidney disease; (2). Have a history of kidney transplants, and (3). Having a mental disorder. We collected secondary demographic data and patient history from medical records. Chi-square analysis with 3x2 or 2x2 tables and the Fishers exact test was used to determine the relationship of clinical conditions or biological conditions and pain history to the incidence of ESRD. The results showed that the clinical requirements of anemia, hyperglycemia, and hypertriglyceridemia were related to the prevalence of ESRD. History of hypertension, diabetes mellitus, dyslipidemia, and family history of ESRD are associated with an increased incidence of ESRD.