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Flavonoid Derivatives from The Leaves of Muntingia calabura L.
Fera Kurniadewi*) Hanhan Dianhar, Muktiningsih, Irma Ratna Kartika, Dewi Aini, Siti Tri Septianingrum
Chemistry Study Program, Universitas Negeri Jakarta, Jalan Rawamangun Muka, Jakarta 13220
*fera[at]unj.ac.id
Abstract
The Isolation and Purification of ethyl acetate fraction from Muntingia calabura leaves have resulted three flavonoid derivatives. UV-Vis, 1H-NMR dan 13C-NMR data showed that isolate compounds are 2,4-dihydroxychalcone (1), 3,7-dimetoxy-5-hydroxyflavon (2) and 3,5,7-trihydroxy-8-methoxyflavone (3). The antioxidant evaluation against 2,2-diphenyl-1-picrylhydrazyl (DPPH), compound (3), showed to be a very high activity (IC50 3,7 x109 ppm). The isolated compounds were also evaluated for their cytotoxic activities against murine leukemia P-388 cells resulted that all isolated compounds were inactive.
Keywords: Antioxidant, cytotoxic activity, flavonoid, Muntingia calabura
Topic: Biochemistry, Biotechnology and Pharmacy
Link: https://ifory.id/abstract/jkN4dqKrYQPC
Conference: International Conference on Science and Technology Applications (ICOSTA 2019)
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