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Low-cost sensor is now widely used in various application ranging from the environment to daily live application. On the other hand, the low-cost sensor signal is dealing with noises due to external disturbances, quality of sensor material, or its electronic circuit. The raw data provided by the low-cost sensor is also still in digital n-bit data, the conversion to the physical meaning is thus needed. In this paper, the low-cost sensor node as part of Wireless Sensor Network (WSN) for CO measurement based on electrochemical sensor module has been investigated. Although the measurement signal consists of noise, it could be attenuated by applying a digital IIR filter. By applying the Response Surface Method (RSM), the 10-bit data of sensor has been calibrated to the commercially CO detector and resulted in the th-square transfer function equation. The sensor node measurement performance has a strong correlation (R2=0.98) with the performance of the sensor module in the wireless sensor node system. The data has been transmitted well to a gateway with needed settling time about 5 minutes for getting stable measurement condition. The results can be used while dealing with a low-cost sensor in various application.