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Quasi experiment method with pre- experimental, one group pretest-posttest design is used in this research. The research was conducted from March to June 2019 and aimed at finding out students- cognitive achievement on vertebrate learning material before and after using mind mapping. Population in this research is students of tenth grade MIPA in SMA Negeri 1 Cigombong academic year 2018/2019, with 32 students as experimental group. Data collection techniques used is multiple choice questions to find out students- achievement and questionnaire to measure response towards teaching learning process. The N-gain score for pretest and postest shows medium criteria of 56%. The average result of Pretest before using mind mapping learning material is 47 with cognitive achievement category considers as low. The average result of posttest after using mind mapping learning material is 77 with cognitive achievement category listed as good. On the other hands, teachers- response towards mind mapping learning material is positive, it can be seen from the result of the questionnaire score 94,3%. While students- response is 78% like the teaching learning process using picture media and 63% students like the use of group work, 66% students felt bored with identical learning source. It can be concluded that mind mapping learning material is effective in improving students- cognitive achievement.