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Abstract – Healthy and clean living behavior is the reference in health development. It is a behavior that is applied to create a healthy and prosperous society. In 2016, public health center Marga I, was the lowest in health and clean living behavior at Tabanan Regency which is about 8,6%. The effort of Health Indonesia Program to improve health and clean living behavior is to carry out health promotion through a family approach. The purpose of this study was to determine the effect of health promotion through family approach toward the community knowledge of health and clean living behavior in public health centre I Marga, Tabanan. This study employed the pre-experimental design with One Group Pretest Posttest Design. There were 109 respondents recruited as the sample of the study which were selected by using Stratified Sampling technique. The result of this study showed that 88.1% of community had moderate knowledge about health and clean living behavior through family approach, and 11.9% of the community had poor knowledge. 100% of the community had good knowledge about health and clean living behavior after giving health promotion through family approach. There was a significant correlation between health promotion through family approach toward community knowledge to apply healthy and clean living behavior. Community are expected to apply information and promotion in implementing healthy and clean living behavior.