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Diabetes mellitus (DM) is the fourth causes of non-communicable diseases. DM is caused by an altered insulin secretion, function or both. One of the risk factor of Coronary Heart Disease for patient with DM type 2 is dyslipidemia. Dyslipidemia is a lipid profile abnormality such as the increasing of total cholesterol, triglyceride, LDL and the decreasing of HDL level. At DM condition, patients will encounter a lipid profile change such as hypercholesterolemia, hypertriglyceride and the increasing of LDL level. The aim for this study was to see the capacity of banana peel waste product in order to decrease glucose, triglyceride and LDL-Cholesterol level on streptozotocine inducted Rattus norvegicus. This study is an experimental research with pre and post-test control design. Samples included for this research were 25 Rattus norvegicus. Data were analyzed with wilcoxon test, kruskall wallis, and mann withney test. The duration for this study was 21 days. The glucose and LDL level data were taken twice during the research; before and after the experiment. Analysis result on Utilization of banana peel waste product to decrease glucose, triglyceride and LDL level on diabetic rat (p=0.025;p=0.043;p=0.043). The Banana peel have antihyperglicemic and antidyslipidemic capacity on diabetic rat.