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THE INFLUENCE OF MACKEREL FLESH CONSUMPTION TOWARDS THE NUMBER OF PURKINJE CELL IN RAT (Rattus norvegicus) CEREBELLUM CONGENITAL HYPOTHYROID
Idiani Darmawati1*, Rijal Dwi Saputro2, Zulkhah Noor3

1,2,3. Faculty of Medicine and Healt Science Study Programe,
Universitas Muhammadiyah Yogyakarta.
Jalan Lingkar Selatan Taman Tirto Kasihan Bantul DIY, Indonesia
Email: idiani2001[at]yahoo.com, idiani[at]umy.ac.id


Abstract

Early detection through screening of congenital hypothyroid is not a regular government programs so that cases of congenital hypothyroid can not be managed appropriately Therefore it needs to be done the research benefits the granting of a bloated fish containing omega-3 on congenital hypothyroid as a food supplement to stimulate nerve growth especially brain development. Sample of this research pups of a white rat (Rattus norvegicus). 30 of rat is divided into 6 groups of 5 of each tail. Four groups induced hypothyroid on day 5 gestation until nenonatus day 15, and two other groups normally. Thyroxine and mackerel were given on 21st day after birth until the 8th week. Histology and preparations made of cells purkinje after being observed in the cerebellum. Number of Purkinje cells analyzed with One-way Anova continued multiple comparison test. The result are number of purkinje cells in the normal group, normal + mackerel, hypothyroid, hypothyroid+mackerel, hypothyroid treatment with thyroxine, thyroxine treatment with hypothyroid+mackerel as follows: 60±12, 71±16, 40±6, 64±7, 70±5, 65±20. Average number of purkinje cells in group that got mackerel significantly (p<0,05) increased compared with hypothyroid. The conclusion is supplementation mackerel fish increased the number of purkinje cells in cerebellum rat congenital hypothyroid.

Keywords: congenital hypothyroid, mackerel fish, omega-3, purkinje cells

Topic: International Symposium of Engineering, Technology, and Health Sciences

Link: https://ifory.id/abstract/mrkgcx6NfJHw

Conference: The 3rd International Conference on Sustainability and Innovation (ICoSI 2019)

Plain Format | Corresponding Author (Idiani Darmawati)

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